The song "Kyrie" by Mr. Mister is about the journey of life and searching for meaning. The title "Kyrie" comes from the Greek phrase for "Lord have mercy" and reflects the idea of calling out for help as one navigates one's own path in life. The lyrics talk about facing difficult struggles, reflecting on one's past and seeking a better path for the future. The chorus repeats the phrase "Kyrie eleison" to emphasize the need for help and reflection throughout the journey. The song encourages listeners to travel down the road of life, seek humility and surrender to the unknown, while also advocating for courage and strength in the process.