The song "You and Me" by Niall Horan speaks about a relationship between two people who are trying to make it work despite the challenges they face. The lyrics express a sense of freedom and youthfulness, with the singer stating that his heart is wild and free. However, he acknowledges that life can be difficult and unpredictable, and that he doesn't know where he's going, but he will always come back to his partner.

The chorus describes his desire for his partner to wait for him, despite the fact that time has never been on their side. He acknowledges that he leads a selfish life, but assures her that everything he's doing is for both of them. The guitar solo adds an emotional element to the song, portraying the longing and passion the singer feels towards his partner.

In the second verse, the singer hears his partner crying from a distance, but promises her that he will always be there for her. He sees a future with her, even if the road is hard, assuring her that he will be with her until the end.

The outro reinforces the idea that the singer knows who he wants to be in life, and it ultimately ends with his partner. The song thus highlights the importance of love and determination in making a relationship work, despite the challenges that may arise.