The song "Nothin' On You" by B.o.B featuring Bruno Mars is a romantic track about a man who only has eyes for his love interest. Despite the many beautiful women all over the world, the singer acknowledges that none of them compare to his significant other. He emphasizes that he's done his fair share of chasing women in the past, but nothing ever came of it. He acknowledges that his past behavior may have impacted his reputation, but it doesn't bother him because he is committed to his current love interest.

The chorus emphasizes the fact that his time would be wasted chasing other women because they simply can't compare to his significant other. He reiterates that while other women may say hello or try to get his attention, he doesn't pay them any mind because they have "nothin' on" his love interest.

The second verse highlights how special his significant other is, describing her as unique and nothing like anyone he's ever met before. He acknowledges her strengths, including her independence and ability to keep it real. He compares her to Wonder Woman and himself to Mr. Fantastic, showcasing the power dynamic between them.

The bridge emphasizes the fact that she's always on his mind, to the point that it doesn't matter where he is or what he's doing, he always finds himself thinking about her.

Overall, the song is a declaration of love and commitment, with the singer emphasizing that he's done playing games and is fully committed to his significant other, who he believes is the most special woman in the world, no matter where he goes.