"Loco" by Chris Lebron & Arcángel is a Spanish-language love song that delves into the infatuation the singer has with their lover. The song opens with Chris Lebron asking who made the person so beautiful and who put the light in their smile that captures his heart. The chorus expresses the overwhelming effect the person has on him, causing him to lose focus as he gradually falls deeper and deeper in love with them.

In verse one, Chris Lebron states he has no doubt that the person has him bad, comparing his search for someone like them to sailing the seas and not finding another like them. He goes to the hospital seeking a cure for his obsession, but instead, his senses are dulled, and he's lost in thoughts of the person.

Verse two is performed by Arcángel, emphasizing the singer's patience and years spent waiting for the right person with whom to share his love. He offers his home, filled with bright colors, flowers, and songbirds, as a paradise for them to share. He describes how their relationship is an infinite love story, and though love may be a sin, he's willing to take the risk because the person brings him happiness and lifts him out of his darkest moments.

Chris Lebron continues in verse three, admitting that being around the person has him on the verge of insanity. They solve his bitter moods, and he wants to give them the world to show his appreciation for the love they share.

The song concludes with a joint chorus between Chris Lebron and Arcángel, expressing their craze for the person and how everything about them drives them crazy. They remark that the person is their happiness and they are a little crazy for them. In summary, the song speaks to the feelings of being in love, adoring, and tremendous craving for someone.