The song "Uptown" is about Drake's success and rise to fame. He boasts about his accomplishments and status in the rap game while also taking shots at those who doubted him or gave him advice he didn't agree with. The chorus emphasizes his confidence and success, with lines like "you can run and tell my city it's on" and "best believe I understand."

The verses give more detail about Drake's journey to the top, including mentions of his work ethic and dedication to his own style. He references other rappers who are unhappy with their own careers and situations, but Drake is content with how things are going for him.

The second verse includes some playful and boastful lines, such as "damn, whose line is it anyways?" and "I'm on fire, yup, I've been ablaze." He also mentions celebrities and fame, with lines like "now she's famous and the paparazzi starts to shoot her."

Bun B's verse continues the theme of success and overcoming criticism, with lines like "the best that ever did it and doin' it on a new song." Lil Wayne's verse is more aggressive, with references to violence and his own superiority. However, it still fits with the overall theme of the song - that he and his fellow rappers are on top and not to be messed with.