The song "Not You Too" by Drake featuring Chris Brown revolves around a relationship that has gone sour because of the narrator's inability to trust his partner. The lyrics convey deep hurt and vulnerability, with the main theme being trust issues. The chorus emphasizes the emotional and psychological pain that the narrator is experiencing, describing it as hurting deeply inside for the first time in a long time.

The first verse sees Drake questioning trust, and the person he's talking to. He's aware of the dangers of the entertainment industry and acknowledges that he needs to watch his back even when he's in the studio. He expresses his willingness to be truthful about his own relationships, though he's unsure if his partner shares the same sentiment. However, he still wants to make his partner feel at ease and free of their worries by taking on their burdens.

The second verse has both Drake and Chris Brown exchanging verses about a love that ended. Drake talks about how his partner was everything he needed and how he made her feel, but it seems that she hid something from him that he found out too late. He confronts her about it, but his love for her is still evident.

The bridge repeats the word "Trust" several times, which reiterates the main theme of the song. This is followed by a verse where Drake tries to rationalize with his partner, convincing her that trust is the key and that he can set her free.

In the outro, Drake expresses his confusion as to how he didn't see the signs and how his friends were also blindsided by the relationship's end. He realizes that there's no going back to how things were, and the song ultimately ends with a sense of sadness and resignation.