"Rick Sanchez vs GLaDOS" is a rap battle between two iconic characters, Rick Sanchez from "Rick and Morty" and GLaDOS from the video game "Portal." Each verse is performed by different artists, giving a distinct voice to each character.

In the song, Rick Sanchez starts by boasting about his intelligence and mocking GLaDOS for her outdated design. He belittles her abilities and makes crude remarks about her functionality. He uses explicit language and references to adult themes to assert his dominance over GLaDOS.

GLaDOS, in response, uses her sharp wit and sarcasm to criticize Rick Sanchez. She points out his failures and mocks his unstable personal life. She mentions his obsession with Szechuan Sauce, a reference to a popular episode of "Rick and Morty." GLaDOS claims that Rick's actions have brought misery upon himself and his family. She also taunts Rick about his lack of a wife and implies that his life is in shambles.

In the third verse, Rick continues his verbal assault on GLaDOS. He takes a drunken and nonsensical turn, referencing Eminem's song "Godzilla" and making random remarks about his own abilities. The lyrics become more chaotic, with Rick spewing out catchphrases and referencing events from the show. Morty briefly interjects with concerned remarks, showing the chaotic nature of Rick's actions.

GLaDOS then joins with Wheatly, another character from "Portal," in the fourth verse. They criticize the quality of the show and mock its fanbase. They criticize the writers and suggest that the show's humor is based on fetishistic content. GLaDOS also makes a wordplay on the phrase "Adult Swim" by mentioning Rick's gene pool. They express their desire to see the show canceled and suggest that the fans are unhealthy and have gained weight due to their obsession.

The outro is a brief exchange between GLaDOS and Wheatly, where GLaDOS expresses her disdain for Wheatly and he humorously ignores her insults, implying that he is oblivious or unaffected by her hatred.

Overall, "Rick Sanchez vs GLaDOS" portrays a confrontational and humorous clash between two beloved characters, with each character using their own strengths to attack and mock the other. The lyrics contain explicit language, adult themes, and references to the respective shows, providing entertainment for fans of both "Rick and Morty" and "Portal."