The meaning behind "Some Girls Are Bigger Than Others" is quite ambiguous, as is typical with many of The Smiths' songs. The chorus seemingly focuses on physical size, stating that some girls are bigger than others and their mothers may be bigger as well. However, the second verse references Antony and Cleopatra opening a crate of ale, which suggests a potential connection to drinking and perhaps objectifying women's bodies. Additionally, the outro seems to suggest a longing for connection, with the exchanging of pillows representing a transfer of intimacy.

Overall, the song may be commenting on societal norms and expectations around physical appearance and objectification of women, while also exploring themes of desire and intimacy. However, as with many of The Smiths' songs, the interpretation is open to artistic interpretation and can be applied in a variety of ways depending on the listener's perspective.