The song "U Remind Me (Lost Boyz Remix)" by Usher featuring Mr. Cheeks explores the theme of past relationships and the memories that come along with them. Mr. Cheeks speaks about a girl he used to date who he thought was loyal and honest, but who ended up being unfaithful to him. Usher resonates with Mr. Cheeks' story, as he sees similarities between the girl that Cheeks described and a girl he is currently interested in.

Usher seems to struggle with his feelings and is hesitant to pursue a relationship with this new girl because of the emotional baggage he carries from the past relationship. He sees the new girl as innocent, but he also recognizes that he was once fooled by someone who appeared to be the same way. The chorus reinforces his hesitation, as he tells the girl that she reminds him of a girl he once knew and all the hurt she caused him.

Mr. Cheeks joins in on the chorus and expresses his own feelings towards the new girl. He enjoys spending time with her and is attracted to her, but he knows that he also struggles with separating his past experiences from his current relationship.

Overall, the song serves as a cautionary tale about the lingering effects of past relationships and the difficulty of moving on. The emotions and memories associated with a past relationship can make it challenging to fully invest in new relationships and trust new partners.