In "F Cancer (Boosie)", Young Thug expresses his disdain for cancer and pays tribute to rapper Boosie, who battled cancer. The song features aggressive and boastful lyrics, discussing Young Thug's success, wealth, and sexual encounters. It also touches upon themes of loyalty, perseverance, and self-confidence.

The chorus highlights Young Thug's determination to overcome obstacles and stay focused on his goals. He claims to be a boss who makes the decisions, leaving his haters feeling insignificant and missing out on his accomplishments. The line "whipping like I'm gifted" suggests that he is skillfully navigating through life, whether it be in his career or personal endeavors. The mention of being in the kitchen could symbolize his ability to cook up success or make something from nothing.

In the verses, Young Thug showcases his lifestyle and mindset. He mentions putting a nine (9mm gun) inside a two-liter bottle, possibly alluding to concealed weapons or the need for protection in his environment. The reference to rasta niggas (referring to the Rastafari religious movement) suggests a connection to Jamaican culture or symbols associated with it, such as loyalty and spirituality.

Young Thug also discusses his reputation as a leader or influencer, with many followers looking up to him. Additionally, he mentions his love for expensive jewelry and his tendency to cheat on his partner. These lines reveal his materialistic desires and struggles with fidelity.

The metaphors and symbols used in the song contribute to its overall meaning. References to "bath time" suggest a moment of relaxation and indulgence. This could represent Young Thug's ability to enjoy the luxuries of his success and indulge in pleasure. The lines about syrup bottles and "Actavis" refer to lean, a narcotic drink often associated with the hip-hop culture. It may signify self-medication or escapism from the pressures of life.

The song's significance lies in its celebration of resilience in the face of adversity and the pursuit of success. Despite setbacks and haters, Young Thug remains focused on his goals and has established himself as a dominant figure in the music industry. The lyrics serve as a testament to his confidence, individuality, and ability to overcome obstacles.

Overall, "F Cancer (Boosie)" carries themes of triumph over adversity, materialism, loyalty, and personal indulgence. It reflects Young Thug's larger-than-life persona and showcases his unwavering determination to succeed in the face of challenges.